Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 1.00 |
| ▸ | DRD3 | P35462 | 3/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.73 |
| ▸ | HTR2B | P41595 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.73 |
| ▸ | CA2 | P00918 | 2/20 | 0.71 |
| ▸ | DRD1 | P21728 | 2/20 | 0.71 |
| ▸ | DRD4 | P21917 | 2/20 | 0.71 |
| ▸ | CA9 | Q16790 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CA12 | O43570 | 1/20 | 0.71 |
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA3 | P07451 | 1/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11049328 | 0.91 | DRD2 (0.84) | DRD2 | |
| SCHEMBL11541003 | 0.91 | DRD2 (0.83) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL11054916 | 0.89 | DRD2 (0.80) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL11464054 | 0.87 | DRD2 (0.77) | DRD2 | |
| Iodopride SCHEMBL10579084 | 0.87 | DRD2 (0.80) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| Iodopride SCHEMBL9502371 | 0.87 | DRD2 (0.80) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL11083117 | 0.87 | DRD2 (0.77) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| Iodopride SCHEMBL30607707 | 0.87 | DRD2 (0.80) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL11046144 | 0.87 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CSLC6A4 | |
| SCHEMBL11051634 | 0.86 | DRD2 (0.76) | DRD2DRD3DRD1DRD4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0105599-A1 | Antiemetic and antipsychotic agents | ADRIA LABORATORIES, INC. (US) | 1984-04-18 | — | — | EP | claimed |
| US-4470977-A | 3-CHLORO-N-(1-ETHYL-2-PYRROLIDINYLMETHYL2-METHOXYBENZAMIDE | ADRIA LABORATORIES, INC. (US) | 1984-09-11 | — | — | US | disclosed |
| EP-0105599-A1 | Antiemetic and antipsychotic agents | ADRIA LABORATORIES, INC. (US) | 1984-04-18 | — | — | EP | disclosed |