Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.77 |
| ▸ | DRD3 | P35462 | 4/20 | 0.74 |
| ▸ | CA2 | P00918 | 2/20 | 0.74 |
| ▸ | DRD1 | P21728 | 2/20 | 0.74 |
| ▸ | DRD4 | P21917 | 2/20 | 0.74 |
| ▸ | CA9 | Q16790 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | CA12 | O43570 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 1/20 | 0.74 |
| ▸ | CA3 | P07451 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.74 |
| ▸ | CA6 | P23280 | 1/20 | 0.74 |
| ▸ | CA5A | P35218 | 1/20 | 0.74 |
| ▸ | CA7 | P43166 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317678 | 0.91 | DRD2 (0.67) | DRD2DRD3CA2DRD1DRD4 | |
| SCHEMBL11054916 | 0.89 | DRD2 (0.80) | DRD2DRD3CA2DRD1DRD4 | |
| Iodopride SCHEMBL10579084 | 0.87 | DRD2 (0.80) | DRD2DRD3CA2DRD1DRD4 | |
| Iodopride SCHEMBL9502371 | 0.87 | DRD2 (0.80) | DRD2DRD3CA2DRD1DRD4 | |
| SCHEMBL11046144 | 0.87 | DRD2 (1.00) | DRD2DRD3CA2DRD1DRD4 | |
| SCHEMBL11050065 | 0.87 | DRD2 (1.00) | DRD2DRD3CA2DRD1DRD4 | |
| Iodopride SCHEMBL30607707 | 0.87 | DRD2 (0.80) | DRD2DRD3CA2DRD1DRD4 | |
| SCHEMBL25796204 | 0.86 | DRD2 (0.73) | DRD2DRD3CA2DRD1DRD4 | |
| Etacepride SCHEMBL2109412 | 0.86 | DRD2 (0.76) | DRD2DRD3CA2DRD1DRD4 | |
| Sulpiride SCHEMBL15475031 | 0.85 | DRD2 (1.00) | DRD2DRD3CA2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431663-A | ANTIULCER AND NEUROLEPTIC AGENTS; ANTIEMETICS | SHIONOGI & CO., LTD. (JP) | 1984-02-14 | — | — | US | disclosed |
| US-4351770-A | Preparation of N(2-pyrrolidinylmethyl)2-methoxy-5-benzenesulfonamidobenzamides | SHIONOGI & CO., LTD. (JP) | 1982-09-28 | — | — | US | disclosed |
| US-4350635-A | ANTIEMETICS, NEUROLEPTIC AGENTS | SHIONOGI & CO., LTD. (JP) | 1982-09-21 | — | — | US | disclosed |
| US-4330472-A | Meta-sulfonamido-benzamide derivatives | SHIONOGI & CO., LTD. (JP) | 1982-05-18 | — | — | US | disclosed |
| US-4328155-A | ANTIEMETIC OR PSYCHOTROPIC AGENT | SHIONOGI & CO., LTD. (JP) | 1982-05-04 | — | — | US | disclosed |
| US-4328344-A | ANTIEMETIC | SHIONOGI & CO., LTD. (JP) | 1982-05-04 | — | — | US | disclosed |