Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.59 |
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | DDX3X | O00571 | 2/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051596 | 0.84 | KMT2A (0.55) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL6725074 | 0.81 | KMT2A (0.72) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL11582992 | 0.80 | POLB (0.63) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL11050011 | 0.80 | MEN1 (0.50) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL11264267 | 0.80 | HTT (0.47) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL11249084 | 0.80 | MEN1 (0.57) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL11053687 | 0.79 | MEN1 (0.55) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL11060416 | 0.79 | GAA (0.49) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11253325 | 0.79 | MAPT (0.43) | KMT2AMEN1MAPTHTTPOLB | |
| SCHEMBL11261263 | 0.79 | MEN1 (0.43) | KMT2AMEN1MAPTHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |