Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053827 | 0.87 | MAPK1 (0.54) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11059010 | 0.84 | MEN1 (0.55) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11260929 | 0.83 | KMT2A (0.50) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11052870 | 0.82 | PDK1 (0.51) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11049616 | 0.82 | HTT (0.50) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11255736 | 0.82 | HTT (0.41) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11049761 | 0.81 | MAPK1 (0.48) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11056782 | 0.81 | MAPK1 (0.48) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11049975 | 0.81 | HTT (0.48) | MAPK1MEN1KMT2AHTTPOLB | |
| SCHEMBL11052077 | 0.80 | MEN1 (0.74) | MAPK1MEN1KMT2APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |