SCHEMBL11052232

SCHEMBL11052232

NC(=O)c1cc(O)c(O)cc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.48
TSHR P16473 3/20 0.48
MAPT P10636 3/20 0.48
KDM4E B2RXH2 3/20 0.48
HPGD P15428 2/20 0.48
HSD17B10 Q99714 2/20 0.48
TDP1 Q9NUW8 2/20 0.46
ALOX15 P16050 1/20 0.46
RECQL P46063 1/20 0.46
CHUK O15111 1/20 0.44
LCK P06239 2/20 0.41
MKNK1 Q9BUB5 1/20 0.39
MKNK2 Q9HBH9 1/20 0.39
CHRNA7 P36544 2/20 0.38
CYP3A4 P08684 1/20 0.38
GAA P10253 1/20 0.38
ESR2 Q92731 1/20 0.38
PTPN1 P18031 1/20 0.38
CA12 O43570 2/20 0.38
CA1 P00915 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23511720 0.94 ALDH1A1 (0.52) ALDH1A1TSHRMAPTKDM4EHPGD
Water SCHEMBL28292285 0.92 ALDH1A1 (0.50) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL28569941 0.84 ALDH1A1 (0.50) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL11666352 0.82 MAPT (0.43) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL3661250 0.80 HSP90AA1 (0.52) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL9673157 0.79 KDM4E (0.44) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL29109119 0.79 ALDH1A1 (0.43) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL4567034 0.77 MAPT (0.51) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL7897387 0.77 HPGD (0.50) ALDH1A1TSHRMAPTKDM4EHPGD
SCHEMBL28877382 0.75 CA12 (0.42) ALDH1A1TSHRMAPTKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4448730-A ANTITUMOR AGENTS RIET BARTHOLOMEUS VAN T 1984-05-15 US disclosed
US-4394389-A ANTITUMOR AGENTS RIET BARTHOLOMEUS VAN T 1983-07-19 US disclosed
US-4263322-A RIBONUCLEOTIDE REDUCTASE INHIBITORS RIET BARTHOLOMEUS VAN T 1981-04-21 US disclosed