Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | CTSG | P08311 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10537080 | 0.81 | SMN1; SMN2 (0.62) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| SCHEMBL8897901 | 0.81 | CYP2D6 (0.62) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| SCHEMBL10456495 | 0.81 | MTOR (0.62) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| SCHEMBL11099911 | 0.78 | MTOR (0.57) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| Triamterene SCHEMBL40707 | 0.77 | ALDH1A1 (1.00) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| Triamterene SCHEMBL5421685 | 0.77 | ALDH1A1 (1.00) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| Triamterene SCHEMBL29531410 | 0.77 | ALDH1A1 (1.00) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| Triamterene SCHEMBL11044581 | 0.76 | ALDH1A1 (0.97) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 | |
| SCHEMBL977030 | 0.75 | CSNK1A1 (0.56) | HSD17B10SMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL3746280 | 0.71 | PIK3CG (1.00) | MTORHSD17B10SMN1; SMN2KDM4EJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4425346-A | ANTIGLAUCOMA AGENTS | SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) | 1984-01-10 | — | — | US | claimed |
| EP-0059524-A1 | Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines | Smith and Nephew Associated Companies p.l.c. (GB) | 1982-09-08 | — | — | EP | claimed |
| US-4425346-A | ANTIGLAUCOMA AGENTS | SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) | 1984-01-10 | — | — | US | disclosed |
| EP-0059524-A1 | Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines | Smith and Nephew Associated Companies p.l.c. (GB) | 1982-09-08 | — | — | EP | disclosed |