Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13713061 | 0.86 | EPHX2 (0.75) | EPHX2HPGDTP53SMN1; SMN2TRPV1 | |
| SCHEMBL11052142 | 0.83 | MEN1 (0.53) | SMN1; SMN2MAPTALDH1A1KMT2APOLB | |
| SCHEMBL11052448 | 0.82 | EPHX2 (0.56) | EPHX2SMN1; SMN2TRPV1MAPTALDH1A1 | |
| SCHEMBL4104599 | 0.80 | EPHX2 (0.61) | EPHX2HPGDSMN1; SMN2TRPV1FAAH | |
| SCHEMBL11054637 | 0.79 | HTT (0.52) | SMN1; SMN2MAPTALDH1A1KMT2AEPHX1 | |
| SCHEMBL11049538 | 0.79 | NPC1 (0.49) | EPHX2HPGDTP53SMN1; SMN2TRPV1 | |
| SCHEMBL11049503 | 0.79 | KMT2A (0.71) | SMN1; SMN2MAPTALDH1A1KMT2AEPHX1 | |
| SCHEMBL17198965 | 0.77 | EPHX2 (0.54) | EPHX2HPGDTRPV1FAAHMAPT | |
| SCHEMBL4104600 | 0.77 | MAPT (0.56) | EPHX2HPGDTRPV1FAAHMAPT | |
| SCHEMBL14595295 | 0.76 | L3MBTL1 (0.66) | EPHX2HPGDSMN1; SMN2TRPV1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |