Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051497 | 0.91 | TSHR (0.55) | KMT2ASMN1; SMN2HTTGAAMEN1 | |
| SCHEMBL10983498 | 0.84 | GAA (0.47) | KMT2ASMN1; SMN2GAAMEN1LMNA | |
| SCHEMBL10981870 | 0.83 | GAA (0.47) | KMT2ASMN1; SMN2GAAMEN1LMNA | |
| SCHEMBL11054892 | 0.82 | KMT2A (0.51) | KMT2AHTTGAAMEN1LMNA | |
| SCHEMBL10832448 | 0.81 | KMT2A (0.53) | KMT2AHTTGAAMEN1LMNA | |
| SCHEMBL10832100 | 0.81 | ALDH1A1 (0.50) | KMT2AHTTMEN1LMNAMAPT | |
| SCHEMBL10924368 | 0.80 | KMT2A (0.47) | KMT2ASMN1; SMN2HTTMAPTKDM4E | |
| SCHEMBL10922854 | 0.79 | KMT2A (0.48) | KMT2ASMN1; SMN2HTTMEN1LMNA | |
| SCHEMBL10979812 | 0.76 | GAA (0.46) | KMT2ASMN1; SMN2HTTGAAMEN1 | |
| SCHEMBL10952008 | 0.75 | MAPT (0.44) | KMT2ASMN1; SMN2HTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453001-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4415568-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4336378-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |