Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5443200 | 0.79 | ALDH1A1 (0.47) | MEN1KMT2APTGS2LMNANPSR1 | |
| SCHEMBL8008240 | 0.71 | KDM4E (0.63) | LMNANPSR1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL7995686 | 0.71 | TEK (0.58) | MEN1KMT2ALMNANPSR1ALDH1A1 | |
| SCHEMBL10964771 | 0.70 | MEN1 (0.48) | MEN1KMT2APTGS2ALDH1A1MAPT | |
| SCHEMBL7996428 | 0.69 | KDM4E (0.53) | LMNANPSR1ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6177031 | 0.69 | MAPK14 (0.69) | — | |
| SCHEMBL11057267 | 0.68 | ALDH1A1 (0.42) | MEN1KMT2APTGS2LMNANPSR1 | |
| SCHEMBL10989518 | 0.67 | ALDH1A1 (0.47) | MEN1KMT2ALMNANPSR1ALDH1A1 | |
| SCHEMBL11169683 | 0.67 | KMT2A (0.44) | MEN1KMT2APTGS2LMNANPSR1 | |
| SCHEMBL11016914 | 0.66 | KMT2A (0.43) | MEN1KMT2APTGS2LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440776-A | ANTIARTHRITIC AGENTS; ANTIALLERGENS; BRONCHODILATOR AGENTS; SKIN DORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-04-03 | — | — | US | disclosed |
| US-4355039-A | Antiinflammatory-4,5-diaryl-2-substituted-thio-imidazoles and their corresponding sulfoxides and sulfones | SCHERING, AKTIENGESELLSCHAFT (DE) | 1982-10-19 | — | — | US | disclosed |
| US-4269847-A | ANTIALLERGENS; DERIVATIVES OF 4,5-BIS/PHENYL-2-MERCAPTO-, THIO-, S | SCHERING AKTIENGESELLSCHAFT (DE) | 1981-05-26 | — | — | US | disclosed |