Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10462625 | 0.90 | AKR1B1 (0.51) | AKR1B1MAPTALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL11217585 | 0.85 | ALDH1A1 (0.47) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL11189387 | 0.84 | AKR1B1 (0.55) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL9870431 | 0.84 | AKR1B1 (0.46) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL11187633 | 0.83 | AKR1B1 (0.54) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL10564057 | 0.83 | AKR1B1 (0.54) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL343740 | 0.83 | MAOA (0.47) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL246198 | 0.82 | ALDH1A1 (0.45) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL10986445 | 0.80 | AKR1B1 (0.39) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL10852984 | 0.79 | AKR1B1 (0.50) | AKR1B1MAPTALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55000372-A | — | — | None | — | — | JP | disclosed |
| JP-55108868-A | — | — | None | — | — | JP | disclosed |
| US-4515946-A | 6,11-Dihydro-11-oxo-dibenz-[b,e]oxepin derivatives | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-05-07 | — | — | US | disclosed |
| US-4417063-A | Process for preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepinacetic acids | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-11-22 | — | — | US | disclosed |
| US-4417063-A | Process for preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepinacetic acids | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-11-22 | — | — | US | disclosed |
| US-4417063-A | Process for preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepinacetic acids | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-11-22 | — | — | US | disclosed |
| EP-0082521-A1 | 6,11-Dihydro-11,-oxo-dibenz(b,e)-oxepin derivatives, methods for their preparation, pharmaceutical compositions containing the same and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-06-29 | — | — | EP | disclosed |
| JP-S55108868-A | DIBENZOXEPIN DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1980-08-21 | — | — | JP | disclosed |
| JP-S55372-A | PREPARATION OF DIBENZOXEPIN DERIVATIVE | DAI ICHI SEIYAKU CO LTD | 1980-01-05 | — | — | JP | disclosed |