Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 15/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053098 | 0.91 | HCAR1 (0.43) | FGFR1CHRNA7HCAR1 | |
| SCHEMBL11054604 | 0.86 | CHRNA7 (0.47) | FGFR1CHRNA7MAPK14WEE1HCAR1 | |
| SCHEMBL11056462 | 0.85 | HCAR1 (0.36) | FGFR1CHRNA7MAPK14WEE1HCAR1 | |
| SCHEMBL11057830 | 0.85 | CDK4 (0.41) | FGFR1CHRNA7MAPK14HCAR1 | |
| SCHEMBL11054654 | 0.84 | CHRNA7 (0.42) | FGFR1CHRNA7WEE1HCAR1 | |
| SCHEMBL11058286 | 0.82 | EGFR (0.45) | FGFR1CHRNA7 | |
| SCHEMBL11057821 | 0.82 | CHRNA7 (0.44) | CHRNA7WEE1HCAR1 | |
| SCHEMBL11059379 | 0.81 | MKNK1 (0.46) | FGFR1CHRNA7MAPK14WEE1 | |
| SCHEMBL11060182 | 0.81 | CHRNA7 (0.43) | FGFR1CHRNA7WEE1HCAR1 | |
| SCHEMBL11050309 | 0.81 | CHRNA7 (0.43) | FGFR1CHRNA7MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |