Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 15/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052901 | 0.91 | HCAR1 (0.43) | EGFRFGFR1MEN1USP2ALDH1A1 | |
| SCHEMBL11050309 | 0.90 | CHRNA7 (0.43) | EGFRFGFR1CHRNA7SRCFGFR2 | |
| Hydrochloric Acid SCHEMBL11343420 | 0.90 | HCAR1 (0.42) | EGFRFGFR1CHRNA7MEN1USP2 | |
| SCHEMBL11055235 | 0.89 | FGFR1 (0.46) | EGFRFGFR1CHRNA7MEN1USP2 | |
| SCHEMBL11058225 | 0.88 | EGFR (0.46) | EGFRFGFR1CHRNA7SRCFGFR2 | |
| SCHEMBL11060182 | 0.88 | CHRNA7 (0.43) | EGFRFGFR1CHRNA7 | |
| SCHEMBL11056764 | 0.87 | CYP1A2 (0.39) | EGFRFGFR1MEN1USP2ALDH1A1 | |
| SCHEMBL11054654 | 0.87 | CHRNA7 (0.42) | EGFRFGFR1CHRNA7 | |
| SCHEMBL11057744 | 0.87 | CHRNA7 (0.49) | FGFR1CHRNA7 | |
| SCHEMBL11054604 | 0.86 | CHRNA7 (0.47) | EGFRFGFR1CHRNA7SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |