Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 13/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056787 | 0.92 | LCK (0.43) | CHRNA7FGFR1LCK | |
| SCHEMBL11061665 | 0.87 | KMT2A (0.41) | CHRNA7FGFR1LCK | |
| SCHEMBL11058286 | 0.87 | EGFR (0.45) | CHRNA7FGFR1 | |
| SCHEMBL11059310 | 0.85 | CHRNA7 (0.44) | CHRNA7FGFR1MAPK14 | |
| SCHEMBL11050309 | 0.85 | CHRNA7 (0.43) | CHRNA7FGFR1MAPK14 | |
| SCHEMBL11060182 | 0.85 | CHRNA7 (0.43) | CHRNA7FGFR1 | |
| SCHEMBL11055055 | 0.85 | CHRNA7 (0.43) | CHRNA7FGFR1MAPK14 | |
| SCHEMBL11054654 | 0.84 | CHRNA7 (0.42) | CHRNA7FGFR1 | |
| SCHEMBL11058225 | 0.83 | EGFR (0.46) | CHRNA7FGFR1ABL1 | |
| SCHEMBL11054604 | 0.83 | CHRNA7 (0.47) | CHRNA7FGFR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |