Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11064607 | 0.81 | SHBG (0.51) | SHBGHKDC1ADRB2ADRB1ADRB3 | |
| Bifluranol SCHEMBL23620730 | 0.72 | SHBG (0.65) | SHBGHKDC1ALOX15HSP90AA1HSP90AB1 | |
| Acefluranol SCHEMBL2110861 | 0.71 | CYP4F2 (0.41) | SHBGALOX15HSP90AA1HSP90AB1MEN1 | |
| SCHEMBL29794231 | 0.68 | ERN1 (0.50) | MEN1KMT2AKDM4ENSD2POLB | |
| SCHEMBL471441 | 0.68 | ERN1 (0.50) | MEN1KMT2AKDM4ENSD2POLB | |
| Bifluranol SCHEMBL131387 | 0.67 | SHBG (0.73) | SHBGHKDC1ADRB2ADRB1ADRB3 | |
| Bifluranol SCHEMBL1650515 | 0.67 | SHBG (0.73) | SHBGHKDC1ADRB2ADRB1ADRB3 | |
| Bifluranol SCHEMBL29928815 | 0.67 | SHBG (0.73) | SHBGHKDC1ADRB2ADRB1ADRB3 | |
| SCHEMBL11559580 | 0.66 | HDAC4 (0.38) | ALOX15ALOX12MEN1KMT2AKDM4E | |
| SCHEMBL11058285 | 0.66 | CYP4F2 (0.44) | SHBGKDM4EMMEESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4427697-A | ANTIESTROGENS | BIOREX LABORATORIES LIMITED (GB) | 1984-01-24 | — | — | US | claimed |
| US-4427697-A | ANTIESTROGENS | BIOREX LABORATORIES LIMITED (GB) | 1984-01-24 | — | — | US | disclosed |