Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11133882 | 0.99 | ABL1 (0.40) | ABL1ESR1RORCHDAC6ALDH1A1 | |
| SCHEMBL11054409 | 0.90 | ESR1 (0.39) | ABL1ESR1RORCHDAC6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11565312 | 0.89 | MAPT (0.36) | ABL1ALDH1A1MAPTOPRM1 | |
| SCHEMBL11061652 | 0.88 | HPGD (0.44) | ESR1HDAC6ALDH1A1HTT | |
| SCHEMBL11053218 | 0.87 | RORC (0.35) | ESR1RORCHDAC6ALDH1A1MAPT | |
| SCHEMBL11053330 | 0.87 | ALDH1A1 (0.35) | ALDH1A1MAPK14HTTOPRM1 | |
| SCHEMBL11054700 | 0.87 | HDAC6 (0.41) | ESR1HDAC6 | |
| SCHEMBL11056263 | 0.86 | ALDH1A1 (0.39) | ESR1RORCHDAC6ALDH1A1MAPT | |
| SCHEMBL11056380 | 0.85 | ALDH1A1 (0.40) | ABL1ESR1ALDH1A1MAPTHTT | |
| SCHEMBL11052205 | 0.85 | CYP1A2 (0.43) | ALDH1A1MAPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0086774-A1 | TREATMENT OF COCCIDIAL INFECTIONS WITH AMIDINOUREA OR AMIDINOTHIOUREA DERIVATIVES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-08-31 | — | — | EP | claimed |
| WO-1983000625-A1 | TREATMENT OF COCCIDIAL INFECTIONS WITH AMIDINOUREA OR AMIDINOTHIOUREA DERIVATIVES | STUDT, WILLIAM, LYON | 1983-03-03 | — | — | WO | claimed |
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |