SCHEMBL11059482

SCHEMBL11059482

CCc1cccc(CC)c1-n1cnc(N(CC)OCCc2ccccc2)nc1=O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.37
MAOA P21397 2/20 0.35
MAOB P27338 2/20 0.35
KMT2A Q03164 1/20 0.35
GSK3B P49841 2/20 0.34
MAT2A P31153 1/20 0.33
ALDH1A1 P00352 3/20 0.32
CYP1A2 P05177 2/20 0.32
CYP2D6 P10635 2/20 0.32
CYP2C9 P11712 2/20 0.32
TSHR P16473 2/20 0.32
CASP1 P29466 2/20 0.32
CYP2C19 P33261 2/20 0.32
CASP7 P55210 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CDK1 P06493 1/20 0.32
CCNB1 P14635 1/20 0.32
GSK3A P49840 1/20 0.32
CDK5 Q00535 1/20 0.32
CDK5R1 Q15078 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11059411 0.94 KMT2A (0.36) HCAR2MAOAMAOBKMT2AGSK3B
SCHEMBL11056353 0.89 HCAR2 (0.34) HCAR2MAOAMAOBKMT2AGSK3B
SCHEMBL11055462 0.89 HCAR2 (0.35) HCAR2MAOAMAOBMAT2AALDH1A1
SCHEMBL11055027 0.86 CHRNA7 (0.44) ALDH1A1P2RX7HPGD
SCHEMBL11052478 0.86 TDP2 (0.33) HCAR2MAOAMAOBKMT2AGSK3B
SCHEMBL11059465 0.83 KMT2A (0.37) HCAR2MAOAMAOBKMT2ACRHR1
SCHEMBL11056305 0.83 MEN1 (0.38) HCAR2MAOAMAOBKMT2AMAT2A
SCHEMBL11347921 0.82 CRHR1 (0.38) MAOBKMT2AMAT2AALDH1A1LMNA
SCHEMBL11053513 0.82 MAPK14 (0.39) HCAR2KMT2AALDH1A1P2RX7HPGD
SCHEMBL11354038 0.79 CRHR1 (0.46) MAOBKMT2AMAT2AALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed