Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.43 |
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11055971 | 0.91 | HCAR1 (0.36) | HCAR1MAT2APRMT5CYP1A2CHRNA7 | |
| SCHEMBL11052461 | 0.91 | HCAR1 (0.40) | HCAR1MAT2ACHRNA7SMN1; SMN2GRM1 | |
| SCHEMBL11401770 | 0.88 | HCAR1 (0.39) | HCAR1CHRNA7KDM4EALDH1A1LMNA | |
| SCHEMBL11056926 | 0.87 | HCAR1 (0.46) | HCAR1MAT2ACYP1A2CHRNA7ALDH1A1 | |
| SCHEMBL11055505 | 0.85 | CHRNA7 (0.40) | HCAR1CYP1A2CHRNA7SMN1; SMN2KDM4E | |
| SCHEMBL11081536 | 0.85 | HCAR1 (0.39) | HCAR1CHRNA7SMN1; SMN2GRM1 | |
| SCHEMBL11061825 | 0.85 | HCAR1 (0.39) | HCAR1CHRNA7GRM1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL11056262 | 0.85 | HCAR1 (0.44) | HCAR1MAT2ACYP1A2CHRNA7ALDH1A1 | |
| SCHEMBL10541722 | 0.84 | HCAR1 (0.43) | HCAR1CHRNA7KDM4EALDH1A1 | |
| SCHEMBL11060209 | 0.83 | HCAR1 (0.41) | HCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |