Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 14/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056383 | 0.96 | HCAR1 (0.40) | HCAR1CRHR1ELANEALOX15CREBBP | |
| SCHEMBL11052461 | 0.88 | HCAR1 (0.40) | HCAR1CRHR1ELANETP53 | |
| SCHEMBL11059494 | 0.84 | CRHR1 (0.38) | HCAR1CRHR1 | |
| SCHEMBL11055471 | 0.84 | HCAR1 (0.38) | HCAR1CRHR1ELANEALOX15TP53 | |
| SCHEMBL11059656 | 0.83 | HCAR1 (0.43) | HCAR1 | |
| SCHEMBL11401770 | 0.83 | HCAR1 (0.39) | HCAR1CRHR1ELANEMAPTTP53 | |
| SCHEMBL11059289 | 0.82 | HCAR1 (0.36) | HCAR1CRHR1ALOX15 | |
| SCHEMBL11053245 | 0.82 | CHRNA7 (0.41) | HCAR1CRHR1MAPTTP53 | |
| SCHEMBL11055569 | 0.82 | CHRNA7 (0.43) | HCAR1 | |
| SCHEMBL11056926 | 0.81 | HCAR1 (0.46) | HCAR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |