Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11137127 | 0.86 | ALDH1A1 (0.49) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL11277645 | 0.84 | ALDH1A1 (0.53) | KDM4EALDH1A1LMNAHPGDRAPGEF4 | |
| SCHEMBL11058243 | 0.83 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL11511410 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNASMN1; SMN2RAPGEF4 | |
| SCHEMBL11055416 | 0.81 | KDM4E (0.50) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL11051094 | 0.79 | ALDH1A1 (0.58) | ALDH1A1LMNAHPGDMEN1KMT2A | |
| SCHEMBL15484217 | 0.79 | KDM4E (0.63) | KDM4EALDH1A1LMNASMN1; SMN2RAPGEF4 | |
| SCHEMBL11134286 | 0.75 | ALDH1A1 (0.37) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL11133351 | 0.73 | ALDH1A1 (0.35) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL11141191 | 0.72 | GAA (0.60) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4418209-A | ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS | WILLIAM H. RORER, INC. (US) | 1983-11-29 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |