Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060773 | 1.00 | CYP19A1 (0.45) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL4260040 | 0.78 | MAOB (0.60) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL27018775 | 0.74 | CYP19A1 (0.46) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL27018784 | 0.74 | CYP19A1 (0.46) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL27779717 | 0.74 | CYP19A1 (0.46) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL5349568 | 0.74 | CYP19A1 (0.46) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL5037122 | 0.72 | TSHR (0.50) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL9050259 | 0.71 | CTRB1 (0.45) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL3816926 | 0.70 | MAOB (0.47) | CYP19A1HSD17B10ARMAOBKDM4E | |
| SCHEMBL9711662 | 0.70 | MAOB (0.56) | CYP19A1HSD17B10ARMAOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010299-B1 | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF HYPERCHOLESTEREMIA | MERCK & CO. INC. (US) | 1984-02-15 | — | — | EP | disclosed |
| EP-0010299-A1 | Pharmaceutical composition useful for the treatment of hypercholesteremia | MERCK & CO. INC. (US) | 1980-04-30 | — | — | EP | disclosed |
| EP-0010299-A1 | Pharmaceutical composition useful for the treatment of hypercholesteremia | MERCK & CO. INC. (US) | 1980-04-30 | — | — | EP | disclosed |