Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.80 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.80 |
| ▸ | PGR | P06401 | 3/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.80 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.80 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.80 |
| ▸ | BLM | P54132 | 1/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | AR | P10275 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | APEX1 | P27695 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061022 | 1.00 | HIF1A (0.80) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| SCHEMBL11061025 | 1.00 | HIF1A (0.80) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| Doxibetasol SCHEMBL140221 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| Doxibetasol SCHEMBL11328088 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| Doxibetasol SCHEMBL13754704 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| Doxibetasol SCHEMBL11328085 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| Doxibetasol SCHEMBL140220 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| Doxibetasol SCHEMBL11885535 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| SCHEMBL9114530 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA | |
| SCHEMBL7612473 | 0.92 | NR3C1 (0.85) | HIF1ANR3C1CYP3A4HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478818-A | Ocular preparation housing steroid in two different therapeutic forms | ALZA CORPORATION (US) | 1984-10-23 | — | — | US | disclosed |
| US-4432964-A | Topical composition containing steroid in two forms released independently from polymeric carrier | ALZA CORPORATION (US) | 1984-02-21 | — | — | US | disclosed |
| US-4304765-A | Ocular insert housing steroid in two different therapeutic forms | ALZA CORPORATION (US) | 1981-12-08 | — | — | US | disclosed |