Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | SRC | P12931 | 6/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11057771 | 0.97 | FGFR1 (0.46) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11056900 | 0.93 | FGFR1 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11053096 | 0.92 | ELANE (0.43) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11055235 | 0.88 | FGFR1 (0.46) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11050354 | 0.88 | KCNH3 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11058225 | 0.87 | EGFR (0.46) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11057674 | 0.87 | FGFR1 (0.41) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11352072 | 0.87 | DNM2 (0.40) | FGFR1EGFRELANEABL1MAPK8 | |
| SCHEMBL11056120 | 0.86 | MKNK1 (0.43) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL11061829 | 0.85 | FGFR1 (0.36) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |