Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 6/20 | 0.85 |
| ▸ | ADORA1 known ✓ | P30542 | 4/20 | 0.85 |
| ▸ | ADORA2A known ✓ | P29274 | 2/20 | 0.85 |
| ▸ | ADORA2B known ✓ | P29275 | 2/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.85 |
| ▸ | DPP4 | P27487 | 1/20 | 0.85 |
| ▸ | MEN1 | O00255 | 1/20 | 0.85 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.85 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.85 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.85 |
| ▸ | GAPDH | P04406 | 1/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.85 |
| ▸ | STAT6 | P42226 | 1/20 | 0.85 |
| ▸ | PI4KA | P42356 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.85 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.85 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.85 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.85 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.85 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL11061662 | 1.00 | ADORA3 (0.85) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL5034951 | 0.95 | ADORA3 (0.77) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL5034955 | 0.95 | ADORA3 (0.77) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL27728504 | 0.93 | ADORA3 (0.80) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL23420216 | 0.92 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL406207 | 0.92 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL2403819 | 0.92 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL23804425 | 0.92 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL1821276 | 0.92 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 | |
| Adenosine SCHEMBL19107495 | 0.92 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4104462-A | Cardioactive adenosine nitrates | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | claimed |
| CN-114502200-A | Antibody drug conjugates | 深圳康源久远生物技术有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-4460765-A | Enzyme inhibitor produced by cultivation of streptomyces microorganisms | SANKYO COMPANY LIMITED (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4104462-A | Cardioactive adenosine nitrates | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | disclosed |
| US-4104462-A | Cardioactive adenosine nitrates | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | disclosed |
| US-4104462-A | Cardioactive adenosine nitrates | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | disclosed |