Adenosine

Adenosine

SCHEMBL1821276

Nc1ncnc2c1ncn2[C@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3

The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 known ✓ P0DMS8 4/20 1.00
ADORA2A known ✓ P29274 1/20 1.00
ADORA2B known ✓ P29275 1/20 1.00
ADORA1 known ✓ P30542 1/20 1.00
DPP4 P27487 1/20 1.00
MEN1 O00255 1/20 1.00
SLC28A1 O00337 1/20 1.00
MAP3K7 O43318 1/20 1.00
SLC28A2 O43868 1/20 1.00
GAPDH P04406 1/20 1.00
MAPK1 P28482 1/20 1.00
STAT6 P42226 1/20 1.00
PI4KA P42356 1/20 1.00
KMT2A Q03164 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
PI4K2B Q8TCG2 1/20 1.00
DOT1L Q8TEK3 1/20 1.00
SLC29A1 Q99808 1/20 1.00
PI4K2A Q9BTU6 1/20 1.00
SLC28A3 Q9HAS3 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenosine SCHEMBL12352425 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL4522263 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL13362239 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL24538665 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL2228590 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL23804425 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL406207 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL23420216 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL2403819 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7
Adenosine SCHEMBL19107495 1.00 ADORA3 (1.00) ADORA3DPP4MEN1SLC28A1MAP3K7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 232 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180344655-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY 2018-12-06 US claimed
WO-2016183217-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY (US) 2016-11-17 WO claimed
US-20250295604-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS YALE UNIVERSITY 2025-09-25 US disclosed
WO-2025151803-A1 ALPHAVIRAL ENCRYPTED RNAS AND THEIR METHODS OF USE AUTONOMOUS THERAPEUTICS, INC. (US) 2025-07-17 WO disclosed
WO-2025151800-A1 PROGRAMMABLE, RNA EDITOR-CONTROLLED NUCLEIC ACID DOSE AMPLIFIERS AND THEIR METHODS OF USE AUTONOMOUS THERAPEUTICS, INC. (US) 2025-07-17 WO disclosed
WO-2024015803-A9 ENCRYPTED RNA AND METHODS OF ITS USE AUTONOMOUS THERAPEUTICS, INC. (US) 2024-08-08 WO disclosed
WO-2024015803-A2 ENCRYPTED RNA AND METHODS OF ITS USE AUTONOMOUS THERAPEUTICS, INC. (US) 2024-01-18 WO disclosed
US-11866475-B2 Modified RNA encoding VEGF-A polypeptides, formulations, and uses relating thereto MODERNATX, INC. (US) 2024-01-09 US disclosed
US-20230383287-A1 ACETYLATED RIBONUCLEIC ACIDS AND USES THEREOF HELIX NANOTECHNOLOGIES INC 2023-11-30 US disclosed
US-20230365970-A1 Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof ALIGOS THERAPEUTICS, INC. (US) 2023-11-16 US disclosed
WO-2023215516-A2 ACETYLATED RIBONUCLEIC ACIDS AND USES THEREOF HELIX NANOTECHNOLOGIES, INC. (US) 2023-11-09 WO disclosed
US-7060708-B2 Active agent delivery systems and methods for protecting and administering active agents NEW RIVER PHARMACEUTICALS INC. (US) 2006-06-13 US disclosed
EP-1490090-A2 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS New River Pharmaceuticals Inc. (US) 2004-12-29 EP disclosed
US-20040063628-A1 Active agent delivery systems and methods for protecting and administering active agents NEW RIVER PHARMACEUTICALS INC. 2004-04-01 US disclosed
WO-2003079972-A2 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS NEW RIVER PARMACEUTICALS INC. (US) 2003-10-02 WO disclosed
EP-0755255-A4 TREATMENT OF TOXOPLASMOSIS RES CORP TECHNOLOGIES INC (US) 2002-07-24 EP disclosed
US-5773424-A PARASITICIDE RESEARCH CORPORATION TECHNOLOGIES, INC. (US) 1998-06-30 US disclosed
US-5631146-A BINDING ADENOSINE OR ADENOSINE-5*-PHOSPHATE AND AMPLIFICATION THE GENERAL HOSPITAL CORPORATION (US) 1997-05-20 US disclosed
EP-0755255-A1 TREATMENT OF TOXOPLASMOSIS UNIVERSITY OF ALABAMA, BIRMINGHAM RESEARCH FOUNDATION (US) 1997-01-29 EP disclosed
WO-1996018398-A1 TREATMENT OF TOXOPLASMOSIS THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION (US) 1996-06-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230365970-A1 Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof NSUN2, SNRPA, SNRPF ADORA3 1358/4885ADORA2A 509/4885ADORA2B 837/4885
US-20230383287-A1 ACETYLATED RIBONUCLEIC ACIDS AND USES THEREOF NSUN2, NSUN3, ADAR ADORA3 707/4885ADORA2A 549/4885ADORA2B 733/4885
US-20250295604-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS PHLPP1, PHLPP2, PLAA ADORA3 32/4885ADORA2A 10/4885ADORA2B 83/4885
US-20180344655-A1 FUNCTIONALIZED POLYMERIC PARTICLES FOR TREATMENT OF GLIOMAS PHLPP1, PHLPP2, PLAA ADORA3 32/4885ADORA2A 10/4885ADORA2B 83/4885
US-20040063628-A1 Active agent delivery systems and methods for protecting and administering active agents HDGF, CTSA, IAPP ADORA3 1906/4885ADORA2A 809/4885ADORA2B 1488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.