Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bemitradine SCHEMBL121173 | 0.88 | KDM4E (0.36) | ADORA2AADORA3ADORA1ALDH1A1CYP1A2 | |
| SCHEMBL11066372 | 0.88 | SRC (0.38) | ALDH1A1HTTCYP1A2KMT2ATDP1 | |
| SCHEMBL11073593 | 0.82 | ALDH1A1 (0.42) | ADORA2AADORA3ADORA1ALDH1A1HTT | |
| SCHEMBL10708265 | 0.79 | KDM4E (0.38) | ALDH1A1HTTCYP1A2MEN1MAPK1 | |
| SCHEMBL10708715 | 0.77 | KDM4E (0.36) | ALDH1A1CYP1A2MEN1MAPK1KMT2A | |
| SCHEMBL11073219 | 0.73 | KDM4E (0.37) | ALDH1A1HTTCYP1A2MEN1MAPK1 | |
| SCHEMBL11060121 | 0.72 | RAD52 (0.39) | ADORA2AALDH1A1POLBCYP1A2MEN1 | |
| SCHEMBL11064822 | 0.70 | MAPT (0.41) | ADORA2AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11070935 | 0.70 | ADORA2A (0.35) | ADORA2AADORA3ADORA1ALDH1A1MEN1 | |
| SCHEMBL9381563 | 0.69 | ADORA2A (0.35) | ADORA2AADORA3ADORA1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | claimed |
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |