Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378832 | 0.87 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2AMAPK1EGLN2 | |
| SCHEMBL11062670 | 0.82 | ADORA2A (0.36) | ALDH1A1POLBCYP1A2MEN1KMT2A | |
| SCHEMBL10706002 | 0.76 | ALDH1A1 (0.36) | ALDH1A1CYP1A2MAPK1TDP1EGLN2 | |
| SCHEMBL9381563 | 0.74 | ADORA2A (0.35) | ALDH1A1MAPK1EGLN2KDM4ESRC | |
| SCHEMBL11060121 | 0.69 | RAD52 (0.39) | ALDH1A1POLBCYP1A2MEN1KMT2A | |
| SCHEMBL11066372 | 0.69 | SRC (0.38) | ALDH1A1CYP1A2KMT2ATDP1EGLN2 | |
| Bemitradine SCHEMBL121173 | 0.69 | KDM4E (0.36) | ALDH1A1CYP1A2MEN1KMT2AMAPK1 | |
| SCHEMBL11070935 | 0.69 | ADORA2A (0.35) | ALDH1A1MEN1KMT2AMAPK1TDP1 | |
| SCHEMBL11151560 | 0.68 | KDM5A (0.40) | ALDH1A1MAPK1EGLN2KDM4ESRC | |
| SCHEMBL11062890 | 0.68 | EGLN1 (0.36) | ALDH1A1POLBCYP1A2MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | claimed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | claimed |
| EP-0129247-A1 | 8-Substituted 7-phenyl-1,2,4-triazolo [2,3-c] pyrimidines-5-amines and amides | G.D. Searle & Co. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4483987-A | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1984-11-20 | — | — | US | disclosed |