Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 14/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | GRM5 | P41594 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31303039 | 0.89 | MAOB (0.64) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL768839 | 0.89 | MAOB (0.64) | MAOBMAOAGRM5NPC1CYP19A1 | |
| Hydrochloric Acid SCHEMBL27916631 | 0.88 | MAOB (0.62) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL11062269 | 0.80 | MAOB (0.42) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL11065204 | 0.79 | MAOB (0.51) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL68886 | 0.79 | RAB9A (0.51) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL8174415 | 0.77 | MAOB (0.59) | MAOBMAOAGRM5NPC1RAB9A | |
| SCHEMBL13204557 | 0.75 | MAOB (0.40) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL26714218 | 0.75 | MAOB (0.40) | MAOBMAOAGRM5NPC1CYP19A1 | |
| SCHEMBL11584003 | 0.74 | PKM (0.59) | MAOBMAOAGRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |