Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | BAZ2A | Q9UIF9 | 5/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11064399 | 0.86 | AOC3 (0.51) | AOC3HTR3ASOS1HTR2BHTR2C | |
| SCHEMBL11071226 | 0.86 | CETP (0.51) | AOC3ADRB1HTR3ASOS1HTR2B | |
| SCHEMBL3015461 | 0.86 | TAAR1 (0.50) | AOC3ADRB1HTR3AHTR6AR | |
| SCHEMBL11065972 | 0.86 | AOC3 (0.48) | AOC3ADRB1HTR3APOLBHTR2B | |
| SCHEMBL11071879 | 0.85 | ADRB1 (0.46) | AOC3ADRB1HTR3APOLBHTR2B | |
| SCHEMBL11071906 | 0.84 | AOC3 (0.49) | AOC3HTR2CHTR1AHTR7HTR6 | |
| SCHEMBL11063733 | 0.82 | AOC3 (0.47) | AOC3HTR3AHTR2CHTR1ACYP1A2 | |
| SCHEMBL11119090 | 0.81 | MAPT (0.52) | AOC3ADRB1HTR3ASOS1HTR2B | |
| SCHEMBL11070162 | 0.81 | SCN4A (0.52) | AOC3HTR3AHTR1AHTR6CETP | |
| SCHEMBL11066808 | 0.81 | AOC3 (0.48) | AOC3ADRB1HTR3ANMT1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005091-B1 | MONOSUBSTITUTED PIPERAZINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) | 1981-11-25 | — | — | EP | claimed |
| US-4479952-A | 1-(4-benzyl-2-thiazolyl) piperazine; antiinflammatory; immunomodulator | SCIENCE UNION ET CIE (FR) | 1984-10-30 | — | — | US | disclosed |