Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | DNM1L | O00429 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11062910 | 0.85 | HTR2C (0.47) | ADRB1AOC3HTR6HTR2CHTR2B | |
| SCHEMBL8067225 | 0.85 | ADRB1 (0.50) | ADRB1AOC3HTR6HTR2CHTR2B | |
| SCHEMBL11064121 | 0.85 | AOC3 (0.51) | ADRB1AOC3HTR6HTR2CHTR2B | |
| SCHEMBL3015461 | 0.84 | TAAR1 (0.50) | ADRB1AOC3HTR6HTR3A | |
| SCHEMBL11062806 | 0.82 | HTR2C (0.50) | ADRB1AOC3HTR6HTR2CHTR2B | |
| SCHEMBL2009116 | 0.79 | HTR2C (0.48) | ADRB1HTR6CTSBCTSSCTSK | |
| SCHEMBL11066808 | 0.79 | AOC3 (0.48) | ADRB1AOC3HTR6HTR1AHTR3A | |
| SCHEMBL11071574 | 0.79 | ERBB2 (0.47) | AOC3HTR1AHTR3APOLB | |
| SCHEMBL3009926 | 0.78 | MAPT (0.46) | MEN1KMT2A | |
| SCHEMBL11071906 | 0.78 | AOC3 (0.49) | AOC3HTR6CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005091-B1 | MONOSUBSTITUTED PIPERAZINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCIENCE UNION ET Cie SOCIETE FRANCAISE DE RECHERCHE MEDICALE (FR) | 1981-11-25 | — | — | EP | claimed |
| US-4479952-A | 1-(4-benzyl-2-thiazolyl) piperazine; antiinflammatory; immunomodulator | SCIENCE UNION ET CIE (FR) | 1984-10-30 | — | — | US | disclosed |