Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | HCN1 | O60741 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11065845 | 0.82 | ALDH1A1 (0.34) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL11055038 | 0.80 | BACE1 (0.32) | — | |
| SCHEMBL9792244 | 0.72 | MDM2 (0.35) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL11090292 | 0.72 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL9792202 | 0.69 | SMN1; SMN2 (0.46) | MAPTKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL11064801 | 0.69 | PTGS2 (0.34) | ALDH1A1HTT | |
| SCHEMBL11077454 | 0.68 | ALDH1A1 (0.33) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9792291 | 0.66 | MEN1 (0.35) | KMT2AMEN1ALDH1A1HPGDTP53 | |
| SCHEMBL7993318 | 0.66 | BACE1 (0.51) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL11048350 | 0.65 | MDM2 (0.35) | MAPTKMT2AMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4458081-A | ANTIINFLAMMATORY, ANALGESIC, ANTICOAGULANT, MUSCLE RELAXANT | SYNTEX (U.S.A.) INC. (US) | 1984-07-03 | — | — | US | disclosed |
| US-4454326-A | 5-Aroyl 6-chloro or 6-bromo 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1,1-di-carboxylates | SYNTEX (U.S.A.) INC. (US) | 1984-06-12 | — | — | US | disclosed |
| US-4347187-A | Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein | SYNTEX (U.S.A.) INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4347186-A | Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein | SYNTEX (U.S.A.) INC. (US) | 1982-08-31 | — | — | US | disclosed |