Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6892230 | 0.87 | CYP2C9 (0.77) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL9821782 | 0.82 | CYP2C9 (0.70) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL5803966 | 0.75 | CYP2C9 (0.60) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL3455097 | 0.74 | RXFP1 (0.64) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL5027088 | 0.73 | MAPT (0.63) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL7936194 | 0.73 | MAPT (0.73) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL12259180 | 0.73 | ALDH1A1 (0.85) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL7262273 | 0.71 | RXFP1 (0.58) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL5027091 | 0.71 | MAPT (0.59) | CYP2C9CYP2C19HPGDLMNAKMT2A | |
| SCHEMBL22534237 | 0.70 | CYP2C19 (0.54) | CYP2C9CYP2C19HPGDLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4458009-A | DECOMPOSING HYDROGEN PEROXIDE ON NUCLEI, BLEACHING | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1984-07-03 | — | — | US | disclosed |
| US-4401751-A | REDUCING FOG, INCREASING SHUTTER SPEED, POLYMER WITH 8-HYDROXYQUINOLIN UNITS | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1983-08-30 | — | — | US | disclosed |
| US-4260674-A | Silver salt photographic material for the production of silver and bubble photographic images with 80% transparency | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1981-04-07 | — | — | US | disclosed |
| US-4065312-A | Process for the production of photographic vesicular images in photographic silver halide material | AGFA-GEVAERT, A.G. (DT) | 1977-12-27 | — | — | US | disclosed |