Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.51 |
| ▸ | ATP4B | P51164 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28235090 | 0.88 | HTR1A (0.44) | ATP4AATP4BHTR1AADRA1DADRA1A | |
| SCHEMBL16964453 | 0.78 | HTR1A (0.60) | ATP4AATP4BHTR1AADRA1DADRA1A | |
| SCHEMBL4721195 | 0.76 | MEN1 (0.52) | MEN1KMT2A | |
| SCHEMBL11711429 | 0.76 | MEN1 (0.49) | MEN1KMT2A | |
| SCHEMBL11069386 | 0.76 | KDM4E (0.41) | MEN1KMT2A | |
| SCHEMBL11069309 | 0.76 | HAVCR2 (0.45) | HTR1AMEN1KMT2A | |
| SCHEMBL9655391 | 0.75 | MEN1 (0.46) | MEN1KMT2A | |
| SCHEMBL29206007 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2A | |
| SCHEMBL4721440 | 0.74 | MEN1 (0.68) | MEN1KMT2A | |
| SCHEMBL31681091 | 0.74 | MEN1 (0.68) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447435-A | HYPOTENSIVE AGENTS | THE BOOTS COMPANY PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| US-4442109-A | 3-Methylthiomethyl-and 3-methylsulfinylmethyl-4-quinolinones useful for treating hypertension | THE BOOTS COMPANY LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |