Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11072566 | 0.91 | LMNA (0.45) | LMNAMAPTTP53DRD2DRD3 | |
| SCHEMBL3761749 | 0.84 | CYP3A4 (0.53) | LMNAMAPTTP53DRD2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11075152 | 0.83 | LMNA (0.54) | LMNAMAPTTP53DRD2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11068467 | 0.83 | LMNA (0.54) | LMNAMAPTTP53DRD2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11078497 | 0.81 | LMNA (0.48) | LMNAMAPTTP53DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL11072427 | 0.81 | LMNA (0.45) | LMNAMAPTTP53DRD2DRD3 | |
| SCHEMBL11076421 | 0.79 | HRH4 (0.42) | DRD2 | |
| SCHEMBL11093911 | 0.78 | RAD52 (0.49) | LMNAMAPTDRD2GRM5CYP3A4 | |
| Hydrochloric Acid SCHEMBL11068298 | 0.78 | SIGMAR1 (0.53) | LMNABLMPMP22 | |
| Hydrochloric Acid SCHEMBL11074583 | 0.77 | HRH4 (0.41) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486433-A | SLOWING HEART RATE | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-04 | — | — | US | disclosed |
| US-4409220-A | Fused-ring amino-pyrazines as bradycardiac agents | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-10-11 | — | — | US | disclosed |
| EP-0047412-A1 | Pyrazines, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1982-03-17 | — | — | EP | disclosed |