Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.62 |
| ▸ | DRD2 | P14416 | 10/20 | 0.60 |
| ▸ | DRD3 | P35462 | 8/20 | 0.60 |
| ▸ | HTR2A | P28223 | 7/20 | 0.60 |
| ▸ | HTR1A | P08908 | 6/20 | 0.60 |
| ▸ | HTR2C | P28335 | 5/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525601 | 0.83 | HSD17B10 (0.72) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL4519876 | 0.78 | KCNH2 (1.00) | KCNH2HTR7 | |
| SCHEMBL13711963 | 0.78 | HTR2A (0.80) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL4522741 | 0.77 | HTR1A (0.79) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL4523970 | 0.77 | KCNH2 (1.00) | KCNH2HTR7 | |
| SCHEMBL7601947 | 0.77 | KCNH2 (0.59) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL4527921 | 0.76 | DRD3 (0.63) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL3239128 | 0.76 | HTR2A (0.74) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL3198969 | 0.75 | KCNH2 (0.72) | KCNH2DRD2DRD3HTR2AHTR1A | |
| SCHEMBL4522956 | 0.75 | DRD3 (1.00) | KCNH2DRD2DRD3HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452798-A | 1-Substituted phenyl-4-alkyl hydantoin piperazine compounds as antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1984-06-05 | — | — | US | disclosed |