Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | PNMT | P11086 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | TACR2 | P21452 | 2/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SHBG | P04278 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22333700 | 1.00 | SIGMAR1 (0.61) | SIGMAR1IGF1RALOX15PNMTTAAR1 | |
| SCHEMBL1448394 | 0.98 | SIGMAR1 (0.63) | SIGMAR1IGF1RALOX15PNMTTAAR1 | |
| SCHEMBL9177318 | 0.92 | SIGMAR1 (0.62) | SIGMAR1IGF1RALOX15PNMTTAAR1 | |
| SCHEMBL22748319 | 0.83 | ABL1 (0.55) | SIGMAR1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL22748429 | 0.83 | ESR1 (0.47) | SIGMAR1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL24454689 | 0.83 | HTR2A (0.52) | SIGMAR1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL22748316 | 0.83 | ESR1 (0.47) | SIGMAR1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL11143625 | 0.83 | ENPP2 (0.49) | SIGMAR1ESR1ADRA2AADORA3TACR2 | |
| SCHEMBL11871334 | 0.83 | KAT8 (0.59) | IGF1RALOX15ESR1ADRA2AADORA3 | |
| SCHEMBL11666919 | 0.83 | KAT8 (0.59) | IGF1RALOX15ESR1ADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471117-A | ANTIDEPRESSANTS AND ANTI-PARKINSON AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-09-11 | — | — | US | disclosed |
| EP-0021807-B1 | 3,4-DIHYDRO-2H-PYRIMIDO (2,1-B) BENZOTHIAZOLES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-03-09 | — | — | EP | disclosed |
| EP-0021806-B1 | 2,3-DIHYDRO-IMIDAZO (2,1-B) BENZOTHIAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-12 | — | — | EP | disclosed |
| US-4364942-A | ANTIDEPRESSANTS, INHIBITORS OF MONOAMINE OXIDASE | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-12-21 | — | — | US | disclosed |
| US-4340738-A | ENZYME INHIBITORS, ANTIDEPRESSANTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-07-20 | — | — | US | disclosed |
| US-4262004-A | MONOAMINE OXIDASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-04-14 | — | — | US | disclosed |
| EP-0021807-A1 | 3,4-Dihydro-2H-pyrimido (2,1-b) benzothiazoles and pharmaceutical compositions containing them | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-01-07 | — | — | EP | disclosed |