Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | DUSP10 | Q9Y6W6 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15045826 | 0.78 | ERN1 (0.46) | ERN1KDM4EGPR3LOXL2ALDH1A1 | |
| SCHEMBL3396523 | 0.78 | KDM4E (0.45) | ERN1KDM4EGPR3LOXL2ALDH1A1 | |
| SCHEMBL28115761 | 0.75 | KDM4E (0.42) | ERN1KDM4EGPR3LOXL2ALDH1A1 | |
| SCHEMBL3394680 | 0.75 | KDM4E (0.42) | ERN1KDM4EGPR3LOXL2ALDH1A1 | |
| SCHEMBL11069998 | 0.74 | ERN1 (0.39) | ERN1KDM4EGPR3LOXL2ALDH1A1 | |
| SCHEMBL7850047 | 0.73 | TLR7 (0.43) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL11064349 | 0.72 | ERN1 (0.44) | ERN1KDM4EGPR3LOXL2ALDH1A1 | |
| SCHEMBL6529277 | 0.72 | TLR7 (0.48) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL11375857 | 0.69 | PI4KA (0.43) | ALDH1A1GAAMEN1KMT2ACYP1A2 | |
| SCHEMBL10595445 | 0.69 | PARP1 (0.46) | ERN1KDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447435-A | HYPOTENSIVE AGENTS | THE BOOTS COMPANY PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| US-4442109-A | 3-Methylthiomethyl-and 3-methylsulfinylmethyl-4-quinolinones useful for treating hypertension | THE BOOTS COMPANY LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |