Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 6/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 6/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 6/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3100845 | 0.98 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11063766 | 0.96 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11875177 | 0.96 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL29619570 | 0.82 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2GAAPPARA | |
| SCHEMBL347929 | 0.82 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2GAAPPARA | |
| SCHEMBL1880580 | 0.81 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2GAAPPARA | |
| SCHEMBL334252 | 0.79 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL11280915 | 0.78 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL14160775 | 0.78 | PIK3CA (0.50) | NPC1RAB9AMAPTKDM4EGAA | |
| SCHEMBL8359677 | 0.76 | HTT (0.47) | MAPTGAAHTTAPPDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4433153-A | Process for the manufacture of 2,6-dichlorobenzoxazole and 2,6-dichlorobenzthiazole | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-02-21 | — | — | US | claimed |