Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.67 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31295159 | 0.89 | HTR2A (0.71) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL23805297 | 0.86 | HTR2A (0.67) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL11263785 | 0.86 | HTR2A (0.67) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL7360256 | 0.85 | HTR2A (0.62) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL6615000 | 0.84 | HTR2A (0.68) | HTR2ALTA4HPLA2G2ATRPM8SRD5A2 | |
| SCHEMBL31295123 | 0.83 | HTR2A (0.71) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL23805211 | 0.83 | HTR2A (0.71) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL28374945 | 0.83 | HTR2A (0.63) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL31089857 | 0.83 | HTR2A (0.60) | HTR2ALTA4HPLA2G2ATRPM8MAPT | |
| SCHEMBL7366247 | 0.82 | HTR2A (0.77) | HTR2ALTA4HPLA2G2ATRPM8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4442295-A | 3-Cyano indoles as intermediates for cardioselective compounds | BOEHRINGER MANNHEIM GMBH (DE) | 1984-04-10 | — | — | US | disclosed |
| EP-0045910-A1 | Indole derivatives and process for their production | Roche Diagnostics GmbH (DE) | 1982-02-17 | — | — | EP | disclosed |