Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238878 | 0.79 | HSD17B10 (0.39) | AOC3ACP3ALDH1A1LMNA | |
| SCHEMBL31404218 | 0.78 | AOC3 (0.44) | ACHEAOC3ALDH1A1L3MBTL1TAAR1 | |
| SCHEMBL28684580 | 0.77 | IDO1 (0.43) | ACHEAOC3IDO1 | |
| SCHEMBL77245 | 0.74 | DPP4 (0.36) | TAAR1IDO1LMNA | |
| SCHEMBL7203410 | 0.74 | ACP3 (0.43) | ACHEAOC3ACP3ALDH1A1GAA | |
| SCHEMBL27977481 | 0.74 | ACHE (0.42) | ACHEAOC3ACP3ALDH1A1GAA | |
| SCHEMBL28932418 | 0.73 | IDO1 (0.47) | ACP3MAPK1IDO1 | |
| SCHEMBL5479093 | 0.72 | AOC3 (0.45) | ACHEAOC3ACP3ALDH1A1GAA | |
| SCHEMBL8750392 | 0.71 | ACHE (0.48) | ACHEAOC3ACP3ALDH1A1GAA | |
| SCHEMBL5177464 | 0.70 | ACHE (0.38) | ACHEAOC3ACP3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4440779-A | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO., INC. (US) | 1984-04-03 | — | — | US | disclosed |
| EP-0068460-A1 | Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents | MERCK & CO. INC. (US) | 1983-01-05 | — | — | EP | disclosed |