Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11078532 | 0.98 | SIGMAR1 (0.59) | SIGMAR1DRD4MC4RALDH1A1TSHR | |
| SCHEMBL1014048 | 0.82 | MEN1 (0.58) | DRD4MEN1NPC1RAB9AKMT2A | |
| SCHEMBL30063704 | 0.80 | SIGMAR1 (0.50) | SIGMAR1DRD4MC4RALDH1A1MEN1 | |
| SCHEMBL30063685 | 0.79 | SIGMAR1 (0.49) | SIGMAR1DRD4MC4RALDH1A1MEN1 | |
| SCHEMBL7368142 | 0.79 | MEN1 (0.51) | SIGMAR1DRD4MC4RALDH1A1MEN1 | |
| SCHEMBL576868 | 0.77 | SIGMAR1 (1.00) | SIGMAR1DRD4MC4RKMT2ALMNA | |
| SCHEMBL8188324 | 0.77 | SIGMAR1 (1.00) | SIGMAR1DRD4MC4RKMT2ALMNA | |
| SCHEMBL242970 | 0.77 | SIGMAR1 (1.00) | SIGMAR1DRD4MC4RKMT2ALMNA | |
| SCHEMBL2489199 | 0.77 | SIGMAR1 (1.00) | SIGMAR1DRD4MC4RKMT2ALMNA | |
| SCHEMBL1415730 | 0.77 | SIGMAR1 (1.00) | SIGMAR1DRD4MC4RKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486433-A | SLOWING HEART RATE | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-04 | — | — | US | disclosed |
| US-4409220-A | Fused-ring amino-pyrazines as bradycardiac agents | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-10-11 | — | — | US | disclosed |
| EP-0047412-A1 | Pyrazines, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1982-03-17 | — | — | EP | disclosed |