Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11078869 | 0.90 | MEN1 (0.54) | MEN1KMT2AHRH3NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11072223 | 0.90 | KMT2A (0.54) | MEN1KMT2AHRH3NPC1RAB9A | |
| SCHEMBL11069076 | 0.87 | HSP90AB1 (0.49) | MEN1KMT2ASIGMAR1DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL11068135 | 0.85 | NOS3 (0.49) | SIGMAR1HRH3DRD2 | |
| SCHEMBL30063704 | 0.84 | SIGMAR1 (0.50) | MEN1KMT2ASIGMAR1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11068298 | 0.82 | SIGMAR1 (0.53) | MEN1KMT2ASIGMAR1LMNAALDH1A1 | |
| SCHEMBL30063685 | 0.82 | SIGMAR1 (0.49) | MEN1KMT2ASIGMAR1NPC1RAB9A | |
| SCHEMBL2580524 | 0.79 | MEN1 (0.56) | MEN1KMT2ASIGMAR1NPC1RAB9A | |
| SCHEMBL11069340 | 0.79 | SIGMAR1 (0.61) | MEN1KMT2ASIGMAR1HRH3NPC1 | |
| SCHEMBL30063678 | 0.79 | C5AR1 (0.51) | MEN1KMT2ASIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048702-A1 | BENZAZEPINE DERIVATIVES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-12-24 | — | — | WO | disclosed |
| US-4486433-A | SLOWING HEART RATE | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-04 | — | — | US | disclosed |
| US-4409220-A | Fused-ring amino-pyrazines as bradycardiac agents | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-10-11 | — | — | US | disclosed |
| EP-0047412-A1 | Pyrazines, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1982-03-17 | — | — | EP | disclosed |