⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL2398484 | 0.90 | — | — | |
| Hydrochlorthiazide SCHEMBL28076623 | 0.90 | TSHR (0.32) | — | |
| Hydrochlorthiazide SCHEMBL11664008 | 0.88 | — | — | |
| Hydrochlorthiazide SCHEMBL29120816 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL28250666 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL28184546 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL28278600 | 0.82 | — | — | |
| Hydrochlorthiazide SCHEMBL2807097 | 0.82 | — | — | |
| Hydrochlorthiazide SCHEMBL2396773 | 0.80 | — | — | |
| Hydrochlorthiazide SCHEMBL352730 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4464500-A | Polymeric composition and use thereof | J.H. DIAMOND COMPANY, A FLA CORP. | 1984-08-07 | — | — | US | disclosed |
| US-4128523-A | BLENDS, CRYSTALLINE, ETHYLENE-PROPYLENE-DIENE TERPOLYMER | THE GENERAL TIRE & RUBBER CO. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4102855-A | SULFUR CURED, ETHYLENE-VINYL ACETATE COPOLYMER, ETHYLENE-PROPYLENE-DIENE RUBBER | THE GENERAL TIRE & RUBBER COMPANY (US) | 1978-07-25 | — | — | US | disclosed |