Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Hydrochlorthiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL28834424 | 0.97 | — | — | |
| Hydrochlorthiazide SCHEMBL28184546 | 0.90 | — | — | |
| Pimagedine SCHEMBL29071202 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL2807097 | 0.86 | — | — | |
| Pimagedine SCHEMBL27763610 | 0.84 | — | — | |
| Hydrochlorthiazide SCHEMBL2398484 | 0.84 | — | — | |
| Hydrochlorthiazide SCHEMBL352730 | 0.84 | — | — | |
| Hydrochlorthiazide SCHEMBL28076623 | 0.84 | TSHR (0.32) | — | |
| Hydrochlorthiazide SCHEMBL19858943 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL450348 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108715721-A | A kind of signature coating, signature film and preparation method thereof, in-mold label film and preparation method thereof | 深圳市深大极光科技有限公司 | 2018-10-30 | — | — | CN | claimed |
| CN-101117538-B | Ink absorption layer composition and ink absorption layer sign strip produced thereby | CHINESE BANKNOTE PRINTING AND MINTING CORP | 2010-07-28 | — | — | CN | claimed |
| CN-101117538-A | Ink absorption layer composition and ink absorption layer sign strip produced thereby | CHINESE BANKNOTE PRINTING AND (CN) | 2008-02-06 | — | — | CN | claimed |
| WO-2007081530-A2 | ENDOLUMINAL MEDICAL DEVICE FOR LOCAL DELIVERY OF CATHEPSIN INHIBITORS | MED INSTITUTE, INC. (US) | 2007-07-19 | — | — | WO | claimed |
| CN-110546136-B | Proline-based neuropeptide FF receptor modulators | 研究三角协会 | 2023-07-18 | — | — | CN | disclosed |
| CN-113336720-B | Guanidyl thiazole compound and preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2022-03-18 | — | — | CN | disclosed |
| CN-113336720-A | Guanidyl thiazole compound and preparation method and application thereof | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 2021-09-03 | — | — | CN | disclosed |
| CN-111298186-A | Ulcer wound nursing material and preparation method thereof | 李虹 | 2020-06-19 | — | — | CN | disclosed |
| CN-209161919-U | A kind of signature film and label film | 深圳市深大极光科技有限公司 | 2019-07-26 | — | — | CN | disclosed |
| CN-108715721-A | A kind of signature coating, signature film and preparation method thereof, in-mold label film and preparation method thereof | 深圳市深大极光科技有限公司 | 2018-10-30 | — | — | CN | disclosed |
| US-20170037016-A1 | GUANIDINE COMPOUNDS AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2017-02-09 | — | — | US | disclosed |
| US-9475782-B2 | Guanidine compounds, and use thereof as binding partners for 5-HT5 receptors | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-10-25 | — | — | US | disclosed |
| CN-101466692-A | Thiazol-guanidine derivatives useful as a (beta) - related pathologies | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |
| US-20070299074-A1 | Guanidine Compounds, and Use Thereof as Binding partners for 5-Ht5 Receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2007-12-27 | — | — | US | disclosed |
| US-20070293937-A1 | Endoluminal medical device for local delivery of cathepsin inhibitors, method of making and treating | MED INSTITUTE, INC. | 2007-12-20 | — | — | US | disclosed |
| WO-2007081530-A2 | ENDOLUMINAL MEDICAL DEVICE FOR LOCAL DELIVERY OF CATHEPSIN INHIBITORS | MED INSTITUTE, INC. (US) | 2007-07-19 | — | — | WO | disclosed |
| EP-1716127-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005082871-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2005-09-09 | — | — | WO | disclosed |
| CN-1536989-A | Oral compositions comprising host-respones modulating agent for promoting whole body health | — | 2004-10-13 | — | — | CN | disclosed |
| CN-1309382-A | Printed reading materials able to directly look up annotation signs | SHENG NIAN (CN) | 2001-08-22 | — | — | CN | disclosed |