⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorthiazide SCHEMBL28076623 | 1.00 | TSHR (0.32) | — | |
| Hydrochlorthiazide SCHEMBL11664008 | 0.92 | — | — | |
| Hydrochlorthiazide SCHEMBL29120816 | 0.90 | — | — | |
| Hydrochlorthiazide SCHEMBL11069828 | 0.90 | — | — | |
| Hydrochlorthiazide SCHEMBL2807097 | 0.86 | — | — | |
| Hydrochlorthiazide SCHEMBL2396773 | 0.84 | — | — | |
| Hydrochlorthiazide SCHEMBL352730 | 0.84 | — | — | |
| Hydrochlorthiazide SCHEMBL19858943 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL450348 | 0.83 | — | — | |
| Hydrochlorthiazide SCHEMBL3110285 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106045938-B | A kind of synthetic method of dehydrogenation abietyl B rings and thiazole thiourea compound | 广西大学 | 2018-03-16 | — | — | CN | claimed |
| CN-106045938-A | Synthesis method of dehydroabietic-acid-based B ring-fused-thiazole-thiocarbamide compounds | 广西大学 | 2016-10-26 | — | — | CN | claimed |
| CN-102101846-B | Preparation method of thiazole thiourea derivatives | ZHOU YULIAN | 2012-07-18 | — | — | CN | claimed |
| CN-102101846-A | Preparation method of thiazole thiourea derivatives | ZHANGJIAGANG TIANYOU NEW MATERIAL TECHNOLOGY CO LTD | 2011-06-22 | — | — | CN | claimed |
| CN-106045938-B | A kind of synthetic method of dehydrogenation abietyl B rings and thiazole thiourea compound | 广西大学 | 2018-03-16 | — | — | CN | disclosed |
| CN-106045938-B | A kind of synthetic method of dehydrogenation abietyl B rings and thiazole thiourea compound | 广西大学 | 2018-03-16 | — | — | CN | disclosed |
| CN-106045938-B | A kind of synthetic method of dehydrogenation abietyl B rings and thiazole thiourea compound | 广西大学 | 2018-03-16 | — | — | CN | disclosed |
| CN-106045938-A | Synthesis method of dehydroabietic-acid-based B ring-fused-thiazole-thiocarbamide compounds | 广西大学 | 2016-10-26 | — | — | CN | disclosed |
| EP-2970706-A2 | INORGANIC COMPOSITE COATINGS COMPRISING NOVEL FUNCTIONALIZED ACRYLICS | Henkel AG & Co. KGaA (DE) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014140846-A2 | INORGANIC COMPOSITE COATINGS COMPRISING NOVEL FUNCTIONALIZED ACRYLICS | HENKEL AG & CO . KGaA (DE) | 2014-09-18 | — | — | WO | disclosed |
| CN-102101846-B | Preparation method of thiazole thiourea derivatives | ZHOU YULIAN | 2012-07-18 | — | — | CN | disclosed |
| CN-102101846-B | Preparation method of thiazole thiourea derivatives | ZHOU YULIAN | 2012-07-18 | — | — | CN | disclosed |
| CN-102101846-A | Preparation method of thiazole thiourea derivatives | ZHANGJIAGANG TIANYOU NEW MATERIAL TECHNOLOGY CO LTD | 2011-06-22 | — | — | CN | disclosed |
| CN-102101846-A | Preparation method of thiazole thiourea derivatives | ZHANGJIAGANG TIANYOU NEW MATERIAL TECHNOLOGY CO LTD | 2011-06-22 | — | — | CN | disclosed |
| CN-102101846-A | Preparation method of thiazole thiourea derivatives | ZHANGJIAGANG TIANYOU NEW MATERIAL TECHNOLOGY CO LTD | 2011-06-22 | — | — | CN | disclosed |
| CN-102002007-A | One-pot method for synthesizing 5-amidogen-3-sulfydryl-1,2,4-triazole | ZHANGJIAGANG CITY LANDISEN NEW MATERIAL TECHNOLOGY CO LTD | 2011-04-06 | — | — | CN | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2006-07-06 | — | — | US | disclosed |
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |