Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066224 | 0.95 | SIGMAR1 (0.59) | SIGMAR1USP2GNAI3GNAO1GNAI1 | |
| SCHEMBL11060304 | 0.94 | SIGMAR1 (0.58) | SIGMAR1GNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL11066538 | 0.90 | SIGMAR1 (0.63) | SIGMAR1USP2GNAI3GNAO1GNAI1 | |
| SCHEMBL1554806 | 0.90 | SIGMAR1 (0.57) | SIGMAR1USP2GNAI3GNAO1GNAI1 | |
| SCHEMBL6678936 | 0.83 | SIGMAR1 (0.58) | SIGMAR1GNAI3GNAO1GNAI1HTT | |
| SCHEMBL8508376 | 0.81 | SIGMAR1 (0.54) | SIGMAR1GNAI3GNAO1GNAI1EPHX1 | |
| SCHEMBL8508634 | 0.80 | SIGMAR1 (0.59) | SIGMAR1CHRM5CHRM3 | |
| SCHEMBL11060305 | 0.79 | SIGMAR1 (0.57) | SIGMAR1EPHX1MEN1KMT2ACHRM5 | |
| SCHEMBL29957416 | 0.78 | SIGMAR1 (0.44) | SIGMAR1USP2GNAI3GNAO1GNAI1 | |
| SCHEMBL7748187 | 0.78 | SIGMAR1 (0.56) | SIGMAR1MEN1KMT2ACHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478838-A | VASODILATOR AGENTS | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1984-10-23 | — | — | US | disclosed |
| EP-0083712-A1 | 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives and a process for the preparation thereof | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1983-07-20 | — | — | EP | disclosed |