Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11070233 | 0.90 | SIGMAR1 (0.60) | SIGMAR1CHRM5CHRM3GNAI3GNAO1 | |
| SCHEMBL11066224 | 0.89 | SIGMAR1 (0.59) | SIGMAR1GNAI3GNAO1GNAI1USP2 | |
| SCHEMBL11060304 | 0.88 | SIGMAR1 (0.58) | SIGMAR1GNAI3GNAO1GNAI1 | |
| SCHEMBL6678936 | 0.86 | SIGMAR1 (0.58) | SIGMAR1CHRM5CHRM3OPRD1GNAI3 | |
| SCHEMBL1554806 | 0.84 | SIGMAR1 (0.57) | SIGMAR1OPRD1GNAI3GNAO1GNAI1 | |
| SCHEMBL4559647 | 0.83 | SIGMAR1 (0.46) | SIGMAR1CHRM5CHRM3OPRD1GNAI3 | |
| SCHEMBL8508634 | 0.83 | SIGMAR1 (0.59) | SIGMAR1CHRM5CHRM3OPRD1SMN1; SMN2 | |
| SCHEMBL11060305 | 0.81 | SIGMAR1 (0.57) | SIGMAR1CHRM5CHRM3OPRD1OPRM1 | |
| SCHEMBL1907641 | 0.81 | SIGMAR1 (0.44) | SIGMAR1CHRM5CHRM3OPRD1GNAI3 | |
| SCHEMBL7748187 | 0.80 | SIGMAR1 (0.56) | SIGMAR1CHRM5CHRM3OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478838-A | VASODILATOR AGENTS | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1984-10-23 | — | — | US | disclosed |
| EP-0083712-A1 | 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives and a process for the preparation thereof | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1983-07-20 | — | — | EP | disclosed |