Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131784 | 0.84 | EPHX1 (0.61) | EPHX1MAPTPOLBGAAALDH1A1 | |
| SCHEMBL5713058 | 0.83 | MAPT (0.48) | EPHX1MAPTPOLBGAAALDH1A1 | |
| SCHEMBL935506 | 0.81 | MAPT (0.49) | EPHX1MAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8242190 | 0.80 | MAPT (0.55) | MAPTGAAALDH1A1TDP1KMT2A | |
| SCHEMBL8508507 | 0.79 | MAPT (0.47) | EPHX1MAPTGAASMN1; SMN2KMT2A | |
| SCHEMBL8526299 | 0.78 | ALDH1A1 (0.47) | EPHX1MAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8507733 | 0.77 | EPHX1 (0.48) | EPHX1MAPTGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL7395153 | 0.77 | GAA (0.41) | EPHX1MAPTPOLBGAAALDH1A1 | |
| SCHEMBL1800738 | 0.74 | MEN1 (0.44) | MAPTCNR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL11172746 | 0.74 | MEN1 (0.43) | MAPTCNR2GAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4447436-A | 1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-methylanilino and use as smooth muscle relaxants | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-05-08 | — | — | US | disclosed |
| US-4220647-A | MUSCLE RELAXANTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-09-02 | — | — | US | disclosed |