Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3084018 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MAPTSMN1; SMN2GAANPC1 | |
| SCHEMBL11070949 | 0.78 | EPHX1 (0.44) | ALDH1A1HPGDMAPTSMN1; SMN2GAA | |
| SCHEMBL5713058 | 0.76 | MAPT (0.48) | ALDH1A1HPGDMAPTSMN1; SMN2GAA | |
| SCHEMBL13359814 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HPGDMAPTSMN1; SMN2AGTR1 | |
| SCHEMBL1798419 | 0.76 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTSMN1; SMN2AGTR1 | |
| SCHEMBL24307977 | 0.74 | MAPT (0.55) | ALDH1A1HPGDMAPTGAACYP1A2 | |
| SCHEMBL13326762 | 0.74 | ALDH1A1 (0.49) | ALDH1A1HPGDMAPTSMN1; SMN2AGTR1 | |
| SCHEMBL131784 | 0.73 | EPHX1 (0.61) | ALDH1A1HPGDMAPTSMN1; SMN2GAA | |
| SCHEMBL5608579 | 0.71 | HTT (0.51) | ALDH1A1MAPTSMN1; SMN2GAACYP1A2 | |
| SCHEMBL935506 | 0.71 | MAPT (0.49) | ALDH1A1MAPTSMN1; SMN2GAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834494-A | SEROTONIN 5HT2B/2C RECEPTOR ANTAGONISTS; CNS NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; IRRITABLE BOWEL SYNDROME | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-11-10 | — | — | US | disclosed |
| EP-0707581-B1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-02-26 | — | — | EP | disclosed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |