Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 7/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.46 |
| ▸ | PLK1 | P53350 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11560139 | 1.00 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11258162 | 0.89 | PRSS1 (0.45) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL10250638 | 0.87 | MLYCD (0.47) | EPHX2NR1H4POLBCA1CA2 | |
| SCHEMBL11563442 | 0.86 | PRSS1 (0.45) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL29384484 | 0.86 | PRSS1 (0.47) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11258943 | 0.86 | PRSS1 (0.47) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11249024 | 0.86 | PRSS1 (0.47) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL11559433 | 0.85 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11260978 | 0.84 | PRSS1 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL11255138 | 0.83 | PRSS1 (0.45) | PRSS1F2PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4485105-A | Method of treating hyperlipidemia with 4-(monoalkylamino)benzoic acid amides | AMERICAN CYANAMID COMPANY (US) | 1984-11-27 | — | — | US | disclosed |
| US-4242273-A | ANTILIPEMIC AND ANTICHOLESTEROL AGENTS | AMERICAN CYANAMID COMPANY (US) | 1980-12-30 | — | — | US | disclosed |
| US-4154756-A | HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
| US-4136256-A | HYPOLIPIDEMIC, ANTIATHEROSCLEROTIC | AMERICAN CYANAMID COMPANY (US) | 1979-01-23 | — | — | US | disclosed |