Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10800850 | 0.87 | KMT2A (0.45) | MEN1KMT2APLA2G7ALDH1A1MAPT | |
| SCHEMBL11125673 | 0.80 | MEN1 (0.45) | MEN1KMT2APLA2G7ALDH1A1MAPT | |
| SCHEMBL10800856 | 0.75 | KMT2A (0.45) | MEN1KMT2APLA2G7ALDH1A1MAPT | |
| SCHEMBL10800874 | 0.70 | MEN1 (0.45) | MEN1KMT2APLA2G7ALDH1A1MAPT | |
| SCHEMBL11067241 | 0.70 | TSHR (0.42) | MEN1KMT2AALDH1A1GAATP53 | |
| SCHEMBL11063263 | 0.66 | CYP3A4 (0.32) | LMNATSHRCYP3A4SMN1; SMN2HIF1A | |
| SCHEMBL11067126 | 0.63 | MEN1 (0.46) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL10798396 | 0.62 | TSHR (0.55) | MEN1KMT2AGAATP53TSHR | |
| SCHEMBL11070883 | 0.61 | MEN1 (0.44) | MEN1KMT2AALDH1A1LMNATSHR | |
| SCHEMBL11842041 | 0.59 | TSHR (0.60) | MEN1KMT2AALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4489078-A | Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators | MEAD JOHNSON & COMPANY (US) | 1984-12-18 | — | — | US | claimed |
| US-4366156-A | Antiallergic methods using diazaheterocyclopurines | MEAD JOHNSON & COMPANY (US) | 1982-12-28 | — | — | US | claimed |
| US-4298734-A | PHOSPHODIESTERASE INHIBITORS, BRONCHODILATORS, PERIPHERAL VASODILATORS | MEAD JOHNSON & COMPANY (US) | 1981-11-03 | — | — | US | claimed |